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1

Opioid activity of sendide, a tachykinin NK1 receptor antagonist

Tsukasa Sakurada, Masayuki Yuhki, Makoto Inoue, Chikai Sakurada, Koichi Tan-No, Masataka Ohba, Kensuke Kisara, Shinobu Sakurada

Journal:

European Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 318 KB

english, 1999

2

Intrathecally administered spermine produces the scratching, biting and licking behaviour in mice

Koichi Tan-No, Aki Taira, Kenji Wako, Fukie Niijima, Osamu Nakagawasai, Takeshi Tadano, Chikai Sakurada, Tsukasa Sakurada, Kensuke Kisara

Journal:

Year:

2000

Language:

english

File:

PDF, 378 KB

english, 2000

3

Possible involvement of the peripheral Mu-opioid system in antinociception induced by bergamot essential oil to allodynia after peripheral nerve injury

Komatsu, Takaaki, Katsuyama, Soh, Uezono, Yasuhito, Sakurada, Chikai, Tsuzuki, Minoru, Hamamura, Kengo, Bagetta, Giacinto, Sakurada, Shinobu, Sakurada, Tsukasa

Journal:

Neuroscience Letters

Year:

2018

Language:

english

File:

PDF, 546 KB

english, 2018

4

Development of a New Analgesic Based on Metabolism of Endomorphin, an Endogenous Opioid Peptide

Chikai Sakurada

Journal:

Year:

2005

File:

PDF, 7 KB

2005

5

Major metabolites of substance P degraded by spinal synaptic membranes antagonize the behavioral response to substance P in rats

Chikai Sakurada, Chizuko Watanabe, Shinobu Sakurada, Koichi Tan-No, Tsukasa Sakurada

Journal:

Journal of Pharmaceutical Sciences

Year:

1999

Language:

english

File:

PDF, 82 KB

english, 1999

6

Nociceptin-induced scratching, biting and licking in mice: involvement of spinal NK1 receptors

Tsukasa Sakurada, Sou Katsuyama, Shinobu Sakurada, Makoto Inoue, Koichi Tan-No, Kensuke Kisara, Chikai Sakurada, Hiroshi Ueda, Jun Sasaki

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 395 KB

english, 1999

7

Nociceptin (1–7) antagonizes nociceptin-induced hyperalgesia in mice

Tsukasa Sakurada, Shinobu Sakurada, Sou Katsuyama, Chikai Sakurada, Koichi Tan-No, Lars Terenius

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 287 KB

english, 1999

8

Endomorphin analogues containing D-Pro2 discriminate different μ-opioid receptor mediated antinociception in mice

Shinobu Sakurada, Hiroyuki Watanabe, Takafumi Hayashi, Masayuki Yuhki, Tsutomu Fujimura, Kimie Murayama, Chikai Sakurada, Tsukasa Sakurada

Journal:

British Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 144 KB

english, 2002

9

Spinally-mediated behavioural responses evoked by intrathecal high-dose morphine: possible involvement of substance P in the mouse spinal cord

Tsukasa Sakurada, Kenji Wako, Chikai Sakurada, Yoichi Manome, Koichi Tan-no, Shinobu Sakurada, Kensuke Kisara

Journal:

Year:

1996

Language:

english

File:

PDF, 708 KB

english, 1996

10

Intrathecal substance P (1–7) prevents morphine-evoked spontaneous pain behavior via spinal NMDA-NO cascade

Tsukasa Sakurada, Takaaki Komatsu, Hikari Kuwahata, Chizuko Watanabe, Toru Orito, Chikai Sakurada, Minoru Tsuzuki, Shinobu Sakurada

Journal:

Biochemical Pharmacology

Year:

2007

Language:

english

File:

PDF, 483 KB

english, 2007

11

Spinal ERK activation via NO–cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide

Takaaki Komatsu, Shinobu Sakurada, Kazuhiro Kohno, Hideo Shiohira, Sou Katsuyama, Chikai Sakurada, Minoru Tsuzuki, Tsukasa Sakurada

Journal:

Biochemical Pharmacology

Year:

2009

Language:

english

File:

PDF, 710 KB

english, 2009

12

Nociceptive behavior induced by poly-l-lysine and other basic compounds involves the spinal NMDA receptors

Koichi Tan-No, Akihisa Esashi, Osamu Nakagawasai, Fukie Niijima, Chikai Sakurada, Tsukasa Sakurada, Georgy Bakalkin, Lars Terenius, Takeshi Tadano

Journal:

Year:

2004

Language:

english

File:

PDF, 248 KB

english, 2004

13

Differential involvement of μ1-opioid receptors in dermorphin tetrapeptide analogues-induced antinociception

Hirokazu Mizoguchi, Masayuki Yuhki, Hiroyuki Watanabe, Takafumi Hayashi, Chikai Sakurada, Akihiko Yonezawa, Tsukasa Sakurada, Shinobu Sakurada

Journal:

European Journal of Pharmacology

Year:

2004

Language:

english

File:

PDF, 150 KB

english, 2004

14

Degradation of nociceptin (orphanin FQ) by mouse spinal cord synaptic membranes is triggered by endopeptidase-24.11: an in vitro and in vivo study

Chikai Sakurada, Shinobu Sakurada, Tohru Orito, Koichi Tan-No, Tsukasa Sakurada

Journal:

Biochemical Pharmacology

Year:

2002

Language:

english

File:

PDF, 248 KB

english, 2002

15

Degradation of endomorphin-2 at the supraspinal level in mice is initiated by dipeptidyl peptidase IV: an in vitro and in vivo study

Chikai Sakurada, Shinobu Sakurada, Takafumi Hayashi, Sou Katsuyama, Koichi Tan-No, Tsukasa Sakurada

Journal:

Biochemical Pharmacology

Year:

2003

Language:

english

File:

PDF, 214 KB

english, 2003

16

Differential antagonism of endomorphin-1 and endomorphin-2 spinal antinociception by naloxonazine and 3-methoxynaltrexone

Shinobu Sakurada, Takafumi Hayashi, Masayuki Yuhki, Tsutomu Fujimura, Kimie Murayama, Akihiko Yonezawa, Chikai Sakurada, Mitsuhiro Takeshita, James E. Zadina, Abba J. Kastin, Tsukasa Sakurada

Journal:

Year:

2000

Language:

english

File:

PDF, 236 KB

english, 2000

17

Evidence that nitric oxide-glutamate cascade modulates spinal antinociceptive effect of morphine: a behavioural and microdialysis study in rats

Chizuko Watanabe, Kazuhiro Okuda, Chikai Sakurada, Ryuichiro Ando, Tsukasa Sakurada, Shinobu Sakurada

Journal:

Year:

2003

Language:

english

File:

PDF, 303 KB

english, 2003

18

Involvement of tachykinin NK1 receptors in nociceptin-induced hyperalgesia in mice

Chikai Sakurada, Shinobu Sakurada, Sou Katsuyama, Jun Sasaki, Koichi Tan-No, Tsukasa Sakurada

Journal:

Year:

1999

Language:

english

File:

PDF, 508 KB

english, 1999

19

Selective antagonism by naloxonazine of antinociception by Tyr-d-Arg-Phe-β-Ala, a novel dermorphin analogue with high affinity at μ-opioid receptors

Shinobu Sakurada, Satoshi Takeda, Takumi Sato, Takafumi Hayashi, Masayuki Yuki, Motoharu Kutsuwa, Koichi Tan-No, Chikai Sakurada, Kensuke Kisara, Tsukasa Sakurada

Journal:

European Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 160 KB

english, 2000

20

Differential antinociceptive effects induced by intrathecally administered endomorphin-1 and endomorphin-2 in the mouse

Shinobu Sakurada, Takafumi Hayashi, Masayuki Yuhki, Tohru Orito, James E Zadina, Abba J Kastin, Tsutomu Fujimura, Kimie Murayama, Chikai Sakurada, Tsukasa Sakurada, Minoru Narita, Tsutomu Suzuki, Koic

Journal:

European Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 202 KB

english, 2001

21

Possible involvement of tachykinin NK1 and NMDA receptors in histamine-induced hyperalgesia in mice

Shinobu Sakurada, Tohru Orito, Chikai Sakurada, Takumi Sato, Takafumi Hayashi, Jalal Izadi Mobarakeh, Kazuhiko Yanai, Kenji Onodera, Takehiko Watanabe, Tsukasa Sakurada

Journal:

European Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 316 KB

english, 2002

22

Intrathecal histamine induces spinally mediated behavioral responses through tachykinin NK1 receptors

Shinobu Sakurada, Tohru Orito, Seiichi Furuta, Hiroyuki Watanabe, Jalal Izadi Mobarakeh, Kazuhiko Yanai, Takehiko Watanabe, Takumi Sato, Kenji Onodera, Chikai Sakurada, Tsukasa Sakurada

Journal:

Pharmacology Biochemistry and Behavior

Year:

2003

Language:

english

File:

PDF, 232 KB

english, 2003

23

Differential effects of intraplantar capsazepine and ruthenium red on capsaicin-induced desensitization in mice

Tsukasa Sakurada, Toshihiro Matsumura, Tomoko Moriyama, Chikai Sakurada, Shinya Ueno, Shinobu Sakurada

Journal:

Pharmacology Biochemistry and Behavior

Year:

2003

Language:

english

File:

PDF, 257 KB

english, 2003

24

Involvement of Spinal NMDA Receptors in Capsaicin-Induced Nociception

Tsukasa Sakurada, Kenji Wako, Akinori Sugiyama, Chikai Sakurada, Koichi Tan-No, Kensuke Kisara

Journal:

Pharmacology Biochemistry and Behavior

Year:

1998

Language:

english

File:

PDF, 398 KB

english, 1998

25

Effect of spinal nitric oxide inhibition on capsaicin-induced nociceptive response

Tsukasa Sakurada, Akinori Sugiyama, Chikai Sakurada, Koichi Tan-No, Akihiko Yonezawa, Shinobu Sakurada, Kensuke Kisara

Journal:

Year:

1996

Language:

english

File:

PDF, 729 KB

english, 1996

26

Extracellular signal-regulated kinase (ERK) and nitric oxide synthase mediate intrathecal morphine-induced nociceptive behavior

Takaaki Komatsu, Chikai Sakurada, Mika Sasaki, Kengo Sanai, Minoru Tsuzuki, Giacinto Bagetta, Shinobu Sakurada, Tsukasa Sakurada

Journal:

Neuropharmacology

Year:

2007

Language:

english

File:

PDF, 308 KB

english, 2007

27

Inhibition of ERK phosphorylation by substance P N-terminal fragment decreases capsaicin-induced nociceptive response

Takaaki Komatsu, Hirokazu Mizoguchi, Mika Sasaki, Chikai Sakurada, Minoru Tsuzuki, Shinobu Sakurada, Tsukasa Sakurada

Journal:

Neuropharmacology

Year:

2011

Language:

english

File:

PDF, 447 KB

english, 2011

28

Involvement of the histaminergic system in the nociceptin-induced pain-related behaviors in the mouse spinal cord

Shinobu Sakurada, Hiroyuki Watanabe, Hirokazu Mizoguchi, Akihiko Yonezawa, Tohru Orito, Sou Katsuyama, Atsuo Kuramasu, Chikai Sakurada, Kazuhiko Yanai, Tsukasa Sakurada

Journal:

Year:

2004

Language:

english

File:

PDF, 396 KB

english, 2004

29

Effects of intraplantar injections of nociceptin and its N-terminal fragments on nociceptive and desensitized responses induced by capsaicin in mice

Tsukasa Sakurada, Takaaki Komatsu, Tomoko Moriyama, Mika Sasaki, Kengo Sanai, Tohru Orito, Chikai Sakurada, Shinobu Sakurada

Journal:

Year:

2005

Language:

english

File:

PDF, 233 KB

english, 2005

30

Intrathecal substance P augments morphine-induced antinociception: Possible relevance in the production of substance P N-terminal fragments

Takaaki Komatsu, Mika Sasaki, Kengo Sanai, Hikari Kuwahata, Chikai Sakurada, Minoru Tsuzuki, Yohko Iwata, Shinobu Sakurada, Tsukasa Sakurada

Journal:

Year:

2009

Language:

english

File:

PDF, 454 KB

english, 2009

31

Antinociceptive effects of spinally administered nociceptin/orphanin FQ and its N-terminal fragments on capsaicin-induced nociception

Soh Katsuyama, Hirokazu Mizoguchi, Takaaki Komatsu, Chikai Sakurada, Minoru Tsuzuki, Shinobu Sakurada, Tsukasa Sakurada

Journal:

Year:

2011

Language:

english

File:

PDF, 532 KB

english, 2011

32

Inhibition of dynorphin-converting enzymes prolongs the antinociceptive effect of intrathecally administered dynorphin in the mouse formalin test

Koichi Tan-No, Aki Taira, Tsukasa Sakurada, Makoto Inoue, Shinobu Sakurada, Takeshi Tadano, Takumi Sato, Chikai Sakurada, Ingrid Nylander, Jerzy Silberring, Lars Terenius, Kensuke Kisara

Journal:

European Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 694 KB

english, 1996

33

Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors

Tsukasa Sakurada, Chizuko Watanabe, Kazuhiro Okuda, Akinori Sugiyama, Tomoko Moriyama, Chikai Sakurada, Koichi Tan-No, Shinobu Sakurada

Journal:

Molecular Brain Research

Year:

2002

Language:

english

File:

PDF, 816 KB

english, 2002

34

Differential antagonism of endomorphin-1 and endomorphin-2 supraspinal antinociception by naloxonazine and 3-methylnaltrexone

Shinobu Sakurada, Takafumi Hayashi, Masayuki Yuhki, Tsutomu Fujimura, Kimie Murayama, Akihiko Yonezawa, Chikai Sakurada, Mitsuhiro Takeshita, Takumi Sato, James E Zadina, Abba J Kastin, Tsukasa Sakura

Journal:

Year:

2002

Language:

english

File:

PDF, 150 KB

english, 2002

35

Spinal actions of GR73632, a novel tachykinin NK1 receptor agonist

Chikai Sakurada, Chizuko Watanabe, Makoto Inoue, Koichi Tan–No, Ryuichiro Ando, Kensuke Kisara, Tsukasa Sakurada

Journal:

Year:

1999

Language:

english

File:

PDF, 82 KB

english, 1999

36

Antinociceptive effect of spinally injected l-NAME on the acute nociceptive response induced by low concentrations of formalin

Chikai Sakurada, Akinori Sugiyama, Miho Nakayama, Akihiko Yonezawa, Shinobu Sakurada, Koichi Tan-No, Kensuke Kisara, Tsukasa Sakurada

Journal:

Neurochemistry International

Year:

2001

Language:

english

File:

PDF, 296 KB

english, 2001

37

Evidence that N-terminal fragments of nociceptin modulate nociceptin-induced scratching, biting and licking in mice

Tsukasa Sakurada, Shinobu Sakurada, Sou Katsuyama, Takafumi Hayashi, Chikai Sakurada, Koichi Tan-No, Heléne Johansson, Johan Sandin, Lars Terenius

Journal:

Neuroscience Letters

Year:

2000

Language:

english

File:

PDF, 234 KB

english, 2000

38

Characterization of nociceptive responses and spinal releases of nitric oxide metabolites and glutamate evoked by different concentrations of formalin in rats

Kazuhiro Okuda, Chikai Sakurada, Mitsuo Takahashi, Tatsuo Yamada, Tsukasa Sakurada

Journal:

Year:

2001

Language:

english

File:

PDF, 425 KB

english, 2001

39

The role of spinal nitric oxide and glutamate in nociceptive behaviour evoked by high-dose intrathecal morphine in rats

Chizuko Watanabe, Tsukasa Sakurada, Kazuhiro Okuda, Chikai Sakurada, Ryuichiro Ando, Shinobu Sakurada

Journal:

Year:

2003

Language:

english

File:

PDF, 779 KB

english, 2003

40

Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-d-aspartate receptor mechanism

Koichi Tan-No, Akihisa Esashi, Osamu Nakagawasai, Fukie Niijima, Takeshi Tadano, Chikai Sakurada, Tsukasa Sakurada, Georgy Bakalkin, Lars Terenius, Kensuke Kisara

Journal:

Year:

2002

Language:

english

File:

PDF, 433 KB

english, 2002

41

The degradation of somatostatin by synaptic membrane of rat hippocampus is initiated by endopeptidase-24.11

Chikai Sakurada, Hideyoshi Yokosawa, Shin-Ichi Ishii

Journal:

Year:

1990

Language:

english

File:

PDF, 585 KB

english, 1990

42

2020 Antinociceptive effect of p-hydroxymercuribenzoate through the spinal dynorphin system

Koichi Tan-No, Aki Taira, Tsukasa Sakurada, Chikai Sakurada, Jerzy Silberring, Lars Terenius, Takeshi Tadano, Kensuke Kisara

Journal:

Neuroscience Research

Year:

1997

Language:

english

File:

PDF, 90 KB

english, 1997

43

Spinal ERK2 activation through δ2-opioid receptors contributes to nociceptive behavior induced by intrathecal injection of leucine-enkephalin

Komatsu, Takaaki, Katsuyama, Soh, Mizoguchi, Hirokazu, Sakurada, Chikai, Tsuzuki, Minoru, Sakurada, Shinobu, Sakurada, Tsukasa

Journal:

Year:

2014

Language:

english

File:

PDF, 2.03 MB

english, 2014

44

Neurokinin Receptor Antagonists

Dr Tsukasa Sakurada,Chikai Sakurada,Koichi Tan-No,Kensuke Kisara

Journal:

Year:

1997

Language:

english

File:

PDF, 2.14 MB

english, 1997

45

Suppression of Melanin Synthesis by the Phenolic Constituents of Sappanwood (Caesalpinia sappan)

Mitani, Kaoru, Takano, Fumihide, Kawabata, Tetsuro, Allam, Ahmed, Ota, Mayumi, Takahashi, Tomoya, Yahagi, Nobuo, Sakurada, Chikai, Fushiya, Shinji, Ohta, Tomihisa

Journal:

Year:

2012

Language:

english

File:

PDF, 313 KB

english, 2012

46

cDNA Cloning and Characterization of Rat C5a Anaphylatoxin Receptor

Akatsu, Hiroyasu, Miwa, Takashi, Sakurada, Chikai, Fukuoka, Yoshihiro, Ember, Julia A., Yamamoto, Takayuki, Hugli, Tony E., Okada, Hidechika

Journal:

Microbiology and Immunology

Year:

1997

Language:

english

File:

PDF, 3.00 MB

english, 1997

47

Intrathecal morphine-3-glucuronide-induced nociceptive behavior via Delta-2 opioid receptors in the spinal cord

Komatsu, Takaaki, Katsuyama, Soh, Nagase, Hiroshi, Mizoguchi, Hirokazu, Sakurada, Chikai, Tsuzuki, Minoru, Sakurada, Shinobu, Sakurada, Tsukasa

Journal:

Pharmacology Biochemistry and Behavior

Year:

2016

Language:

english

File:

PDF, 710 KB

english, 2016

48

Development of a New Analgesic Based on Metabolism of Endomorphin, an Endogenous Opioid Peptide

SAKURADA, Chikai

Journal:

YAKUGAKU ZASSHI

Year:

2004

Language:

english

File:

PDF, 723 KB

english, 2004

49

Pro-Carboxypeptidase R Cleaves Bradykinin following Activation

Shinohara, Tsurayuki, Sakurada, Chikai, Suzuki, Takashi, Takeuchi, Oki, Campbell, William, Ikeda, Seiyo, Okada, Noriko, Okada, Hidechika

Journal:

International Archives of Allergy and Immunology

Year:

1994

Language:

english

File:

PDF, 828 KB

english, 1994